INVESTIGADORES
DANTOLA Maria Laura
artículos
Título:
Emission properties of dihydropterins in aqueous solutions
Autor/es:
MARIANA P. SERRANO; MARIANA VIGNONI; MARIA LAURA DANTOLA; ESTHER OLIVEROS; CAROLINA LORENTE; ANDRES H. THOMAS
Revista:
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
Editorial:
ROYAL SOC CHEMISTRY
Referencias:
Lugar: Cambridge; Año: 2011 vol. 13 p. 7419 - 7425
ISSN:
1463-9076
Resumen:
Pterins belong to a class of heterocyclic compounds
present in a wide range of living systems and accumulate in the skin of patients affected by
vitiligo, a depigmentation disorder. The study of the emission of
7,8-dihydropterins is difficult because these compounds are more or less unstable
in the presence of O2 and their solutions are contaminated with
oxidized pterins which have much higher fluorescence quantum yields (FF). In this work, the emission
properties of six compounds of the dihydropterin family (6-formyl-7,8-dihydropterin
(H2Fop), sepiapterin (Sep), 7,8-dihydrobiopterin (H2Bip),
7,8-dihydroneopterin (H2Nep), 6-hydroxymethyl-7,8- dihydropterin (H2Hmp),
and 6-methyl-7,8-dihydropterin (H2Mep)) have been studied in aqueous solution. The
fluorescence characteristics (spectra, FF, lifetimes (tF)) of the
neutral form of these compounds have been investigated using the
single-photon-counting technique. FF and tF values obtained lie in the ranges
3-9 x 10-3 and 0.18-0.34 ns, respectively. The results are compared
to those previously reported for oxidized pterins.