INVESTIGADORES
KAUFFMAN Marcelo Andres
artículos
Título:
Pharmacokinetics and pharmacodynamics of interferon beta 1a in Cebus apella
Autor/es:
LAHOZ MONICA; KAUFFMAN MARCELO; VIDAL ALEJANDRO; PAPOUCHADO MARIANA; DIEZ ROBERTO; NAGLE CARLOS
Revista:
JOURNAL OF MEDICAL PRIMATOLOGY
Editorial:
WILEY-BLACKWELL PUBLISHING, INC
Referencias:
Año: 2009 vol. 38 p. 187 - 191
ISSN:
0047-2565
Resumen:
Background Recombinant human interferon (hIFNb) is indicated for the
treatment of multiple sclerosis. Its effect presents species restriction, thus
lacking biological activity on most mammals. Although there have been
previous studies of the pharmacology of INFb in Old World primates, no
data exists on New World primates. Therefore, we explored its effect on
Cebus apella, a New World monkey, describing the pharmacology of this
molecule when injected by subcutaneous route in this species.
Methods Safety, pharmacokinetics and pharmacodynamics of IFNb were
evaluated in nine Cebus apella individuals.
Results A single subcutaneous injection of 12 · 106 IU of hIFNb1a
resulted in a median AUC(048) (area under the curve) of 14.82 ng/ml,
a Cmax (maximum plasma concentrations) of 1.51 ng/ml and a Tmax (time
to achieve maximum plasma concentrations) of 3 h. IFNb was biologically
active as demonstrated by an increase in neopterin levels. There were no
safety concerns.
Conclusions New World non-human primates are a suitable animal model
for the study of IFNb pharmacology.