INVESTIGADORES
WEISSTAUB Noelia Victoria
artículos
Título:
Medial prefrontal cortex is a crucial node of a rapid learning system that retrieves recent and remote memories
Autor/es:
CAROLINA GONZALEZ; CECILIA KRAMAR; FERNANDO GARAGOLI; JANINE ROSSATO; NOELIA WEISSTAUB; MARTIN CAMMAROTA; JORGE H MEDINA
Revista:
NEUROBIOLOGY OF LEARNING AND MEMORY
Editorial:
ACADEMIC PRESS INC ELSEVIER SCIENCE
Referencias:
Lugar: Amsterdam; Año: 2013 p. 19 - 25
ISSN:
1074-7427
Resumen:
The neocortex is thought to be a distributed learning system that gradually integrates semantic information into the initial mnemonic representation rapidly formed by the hippocampus early after acquisition. Nevertheless, an emerging view suggests that some cortical regions, in particular the medial prefrontal cortex (mPFC), may also have a role during the initial steps of memory consolidation as well as in the recall of recent memories. Here, we show that mPFC plays a critical role during the first few hours of inhibitory avoidance memory consolidation and is necessary for the normal retrieval of both recent and remote memories, supporting the idea that the involvement of neocortical areas in memory processing is not restricted to the late posttraining consolidation phase.