INVESTIGADORES
PEREZ LLORET Santiago
artículos
Título:
Decision-making in Parkinson's disease patients with and without pathological gambling.
Autor/es:
MALCO ROSSI; ELIANA ROLDÁN GERSCOVICH; DELFINA DE ACHAVAL; SANTIAGO PEREZ-LLORET; DANIEL CERQUETTI; ANGEL CAMMAROTA; MARÍA INÉS NOUZEILLES; RAUL FAHRER; MARCELO MERELLO; RAMÓN LEIGUARDA
Revista:
EUROPEAN JOURNAL OF NEUROLOGY
Editorial:
WILEY-BLACKWELL PUBLISHING, INC
Referencias:
Año: 2010 vol. 17 p. 97 - 102
ISSN:
1351-5101
Resumen:
BACKGROUND AND PURPOSE: Pathological
gambling (PG) in Parkinson's disease (PD) is a frequent impulse control
disorder associated mainly with dopamine replacement therapy. As
impairments in decision-making were described independently in PG and
PD, the objective of this study was to assess decision-making processes
in PD patients with and without PG.
METHODS: Seven
PD patients with PG and 13 age, sex, education and disease severity
matched PD patients without gambling behavior were enrolled in the
study. All patients were assessed with a comprehensive neuropsychiatric
and cognitive evaluation, including tasks used to assess decision-making
abilities under ambiguous or risky situations, like the Iowa Gambling
Task (IGT), the Game of Dice Task and the Investment Task.
RESULTS: Compared
to PD patients without gambling behavior, those with PG obtained poorer
scores in the IGT and in a rating scale of social behavior, but not in
other decision-making and cognitive tasks.
CONCLUSIONS: Low
performance in decision-making under ambiguity and abnormal social
behavior distinguished PD patients with PG from those without this
disorder. Dopamine replacement therapy may induce dysfunction of the
ventromedial prefrontal cortex and amygdala-ventral striatum system,
thus increasing the risk for developing PG.