INVESTIGADORES
TALEVI Alan
artículos
Título:
Synthesis of 2-Hydrazolyl-4-Thiazolidinones Based on Multicomponent Reactions and Biological Evaluation Against Trypanosoma Cruzi
Autor/es:
CHIARA PIZZO; CECILIA SAIZ; ALAN TALEVI; LUCIANA GAVERNET; PABLO PALESTRO; CAROLINA BELLERA; LUIS BRUNO BLANCH; DIEGO BENÍTEZ; JUAN J. CAZZULO; AGUSTINA CHIDICHIMO; PETER WIPF; S. GRACIELA MAHLER
Revista:
CHEMICAL BIOLOGY & DRUG DESIGN
Editorial:
WILEY-BLACKWELL PUBLISHING, INC
Referencias:
Año: 2011 vol. 77 p. 166 - 172
ISSN:
1747-0277
Resumen:
A series of 18 novel 2-hydrazolyl-4-thiazolidinones- 5-carboxylic acids, amides and 5,6-a,b-unsaturated esters were synthesized, and their in vitro activity on cruzipain and T. cruzi epimastigotes was determined. Some agents show activity at 37 lM concentration in the enzyme assay. Computational tools and docking were used to correlate the biological response with the physicochemical parameters of the compounds and their cruzipain inhibitory effects.
