Action of nitrogenated and sulfonylated inositol derivatives upon the proliferation in vitro of normal mouse and tumor mouse cells

A.M.EIJÁN,; L.PURICELLI,; E.BAL DE KIER JOFFÉ,; C.ELIAS,; S.R.LEICACH,; R.A.CADENAS

TUMOR BIOLOGY

KARGER

Año: 1994 vol. 15 p. 354 - 360

1010-4283

23. Tumour Biol. 1994;15(6):354-60. Action of nitrogenated and sulfonylated inositol derivatives upon theproliferation in vitro of normal mouse cells and tumor mouse cells. Eiján AM, Puricelli L, Bal de Kier Joffé E, Elías C, Leicach SR, Cadenas RA. Instituto de Oncología Angel H. Roffo, Universidad de Buenos Aires, Argentina. Despite the major advances of cancer chemotherapy during the past 40 years, host toxicities and drug resistance justify the need to continue the search for newantineoplastic agents. In the present work, we have studied the effect of sixsynthetic drugs on the in vitro growth of two murine mammary adenocarcinomas (M3 and MM3), as well as on normal embryonic cells. AI, MIC and MPI are purinescoupled to a sulfonylated inositol, while DIC and DEI have nitrogen mustard assubstituent. Methylsulfonylmucoinositol was the common substituent. Our resultsindicated that only drugs substituted with nitrogen mustards had anantiproliferative effect. DEI was more effective on tumor cells than on normalcells.  PMID: 7997807 [PubMed - indexed for MEDLINE]