Urban air pollution induces alterations in redox metabolism and mitochondrial disfunction in mice brain cortex

CALABRÓ LOPEZ, VALERIA; GARCÉS, MARIANA; CACERES, LOURDES; MAGNANI, NATALIA; MARCHINI, TIMOTEO; FREIRE, AGUSTINA; VICO, TAMARA; MARTINEFSKI, MANUELA; VANASCO, VIRGINIA; TRIPODI, VALERIA; BERRA, ALEJANDRO; ALVAREZ SILVIA; EVELSON, PABLO

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

ELSEVIER SCIENCE INC

Lugar: Amsterdam; Año: 2021

0003-9861

Previous reports indicate that the central nervous system (CNS) is a target of airpollution, causing tissue damage and functional alterations. Oxidative stress andneuroinflammation have been pointed out as possible mechanisms mediating theseeffects. The aim of this work was to study the chronic effects of urban air pollution onmice brain cortex, focusing on oxidative stress markers, and mitochondrial function.Male 8-week-old BALB/c mice were exposed to filtered air (FA, control) or urban air(UA) inside whole-body exposure chambers, located in a highly polluted area ofBuenos Aires city, for up to 4 weeks. Glutathione levels, assessed as GSH/GSSGratio, were decreased after 1 and 2 weeks of exposure to UA (45% and 25%respectively vs. FA; p