Genetic characterization of bovine herpesvirus 4 (BoHV-4) isolates from Argentine cattle suggests a complex evolutionary scenario

PÉREZ, SANDRA; MANRIQUE, JULIETA; MORÁN, PEDRO; ROMEO, FLORENCIA; ANGELINI, HERNÁN; LEUNDA, MARÍA ROSA; PEREYRA, SUSANA; SPETTER, MAXIMILIANO; GONZÁLEZ ALTAMIRANDA, ERIKA; ODEÓN, ANSELMO; JONES, LEANDRO; VERNA, ANDREA

MOLECULAR BIOLOGY REPORTS

SPRINGER

Año: 2020

0301-4851

Bovine herpevsirus 4 (BoHV-4) is a gammaherpesvirus that has been associated with diferent clinical conditions in cattle.In Argentina, BoHV-4 was detected in diverse bovine samples. The aim of this study was to analyze the genetic relationshipof 48 feld BoHV-4 strains isolated from cattle in Argentina. According to thymidine kinase (tk) gene sequences, BoHV-4isolates belong to genotypes 1, 2 and 3. Phylogenetic analyses confrmed the presence of the three previously described viralgenotypes. However, some of the studied isolates presented conficting phylogenetic signals between the studied markers.This suggests a complex evolutionary background, that is a history of recombination, incomplete lineage sorting (deepcoalescence) or a combination of these, which requires further study. These potential events make difcult the diagnosis ofBoHV-4 from clinical samples of cattle and may pose a signifcant problem for the control of the virus in the herds.