Sedative and physiologic effects of tiletamine-zolazepam following buccal administration in cats

MARIA CLAUSSE; SOFIA MARTINEZ; PABLO NEJAMKIN; FLORENCIA LANDIVAR; MARIA JOSE DEL SOLE; PABLO NEJAMKIN; FLORENCIA LANDIVAR; MARIA JOSE DEL SOLE; VERONICA CAVILLA; AUGUSTO M. LORENZUTTI; MANUEL MARTIN FLORES; VERONICA CAVILLA; AUGUSTO M. LORENZUTTI; MANUEL MARTIN FLORES; MARIA CLAUSSE; SOFIA MARTINEZ

JOURNAL OF FELINE MEDICINE AND SURGERY

ELSEVIER SCI LTD

Lugar: Amsterdam; Año: 2020 vol. 22 p. 108 - 113

1098-612X

Objectives The aim of this study was to describe the sedative and some physiological effects of tiletamine?zolazepam following buccal administration (BA) in cats.Methods Seven healthy spayed European Shorthair cats (three males, four female) were studied twice in thisrandomized, blinded, crossover study. Each cat received two doses of tiletamine?zolazepam by BA: the lowdose(LD) consisted of 5 mg/kg of each drug, and the high dose (HD) consisted of 7.5 mg/kg of each. Baselinesystolic blood pressure (SAP), heart rate (HR), respiratory rate (RR) and a sedation score were recorded prior toadministration of each treatment. The same variables plus the percentage of hemoglobin saturated with oxygen asmeasured by pulse oximetry (SpO2) were recorded at predefined intervals for the next 2 h.Results All cats completed the study. No retching or vomiting were observed. Hypersalivation was observed in0/7 and 3/7 for LD and HD, respectively (P = 0.2). There were significant changes in scores over time for posture,response to clippers and response to manual restraint for both groups, without differences between groups. RR,HR and SAP changed significantly over time. SAP and RR were significantly lower for HD than for LD. No values forhemoglobin saturation