INVESTIGADORES
PITOSSI Fernando Juan
artículos
Título:
IL-6: a cytokine to forget
Autor/es:
BALSCHUN, D; WETZEL, W; DEL REY, A.; PITOSSI FJ; SCHNEIDER, H; ZUSCHRATTER, W; BESEDOVSKY, H
Revista:
FASEB JOURNAL
Editorial:
FEDERATION AMER SOC EXP BIOL
Referencias:
Lugar: Bethesda; Año: 2004 p. 1788 - 1790
ISSN:
0892-6638
Resumen:
It is known that proinflammatory cytokines such as interleukin-6 (IL-6) are expressed in the
central nervous system (CNS) during disease conditions and affect several brain functions
including memory and learning. In contrast to these effects observed during pathological
conditions, here we describe a physiological function of IL-6 in the healthy brain in synaptic
plasticity and memory consolidation. During long-term potentiation (LTP) in vitro and in freely
moving rats, IL-6 gene expression in the hippocampus was substantially increased. This increase
was long lasting, specific to potentiation, and was prevented by inhibition of N-methyl-Daspartate
receptors with (±)-2-amino-5-phosphonopentanoic acid (AP-5). Blockade of
endogenous IL-6 by application of a neutralizing anti-IL6 antibody 90 min after tetanus caused a
remarkable prolongation of LTP. Consistently, blockade of endogenous IL-6, 90 min after
hippocampus-dependent spatial alternation learning resulted in a significant improvement of
long-term memory. In view of the suggested role of LTP in memory formation, these data
implicate IL-6 in the mechanisms controlling the kinetics and amount of information storage.N-methyl-Daspartate
receptors with (±)-2-amino-5-phosphonopentanoic acid (AP-5). Blockade of
endogenous IL-6 by application of a neutralizing anti-IL6 antibody 90 min after tetanus caused a
remarkable prolongation of LTP. Consistently, blockade of endogenous IL-6, 90 min after
hippocampus-dependent spatial alternation learning resulted in a significant improvement of
long-term memory. In view of the suggested role of LTP in memory formation, these data
implicate IL-6 in the mechanisms controlling the kinetics and amount of information storage.