Nigral neurodegeneration triggered by striatal AdIL-1 administration can be exacerbated by systemic IL-1 expression

CLARA POTT GODOY; CARINA FERRARI; FERNANDO J. PITOSSI

JOURNAL OF NEUROIMMUNOLOGY

ELSEVIER SCIENCE BV

Año: 2010 vol. 222 p. 29 - 39

0165-5728

Neuroinflammation has been proposed as an important component of Parkinson's Disease (PD) aetiology and/ or progression. However, the inflammatory components and the mechanisms underlying their effects are only partially known. By injecting an adenovirus expressing IL-1 in the striatum, we provoked progressive neurodegeneration of dopaminergic cells in the substantia nigra, motor symptoms and microglial activation. All these effects were attenuated by an anti-inflammatory treatment. Interestingly, peripheral inflammatory stimuli exacerbated IL-1â induced neurodegeneration and the central inflammatory reaction. These data provide evidence that central, chronic IL-1â expression can trigger and systemic IL-1â exacerbate nigral neurodegeneration and highlight the functional relevance of this cytokine in PD.flammation has been proposed as an important component of Parkinson's Disease (PD) aetiology and/ or progression. However, the inflammatory components and the mechanisms underlying their effects are only partially known. By injecting an adenovirus expressing IL-1 in the striatum, we provoked progressive neurodegeneration of dopaminergic cells in the substantia nigra, motor symptoms and microglial activation. All these effects were attenuated by an anti-inflammatory treatment. Interestingly, peripheral inflammatory stimuli exacerbated IL-1â induced neurodegeneration and the central inflammatory reaction. These data provide evidence that central, chronic IL-1â expression can trigger and systemic IL-1â exacerbate nigral neurodegeneration and highlight the functional relevance of this cytokine in PD.flammatory components and the mechanisms underlying their effects are only partially known. By injecting an adenovirus expressing IL-1 in the striatum, we provoked progressive neurodegeneration of dopaminergic cells in the substantia nigra, motor symptoms and microglial activation. All these effects were attenuated by an anti-inflammatory treatment. Interestingly, peripheral inflammatory stimuli exacerbated IL-1â induced neurodegeneration and the central inflammatory reaction. These data provide evidence that central, chronic IL-1â expression can trigger and systemic IL-1â exacerbate nigral neurodegeneration and highlight the functional relevance of this cytokine in PD.flammatory treatment. Interestingly, peripheral inflammatory stimuli exacerbated IL-1â induced neurodegeneration and the central inflammatory reaction. These data provide evidence that central, chronic IL-1â expression can trigger and systemic IL-1â exacerbate nigral neurodegeneration and highlight the functional relevance of this cytokine in PD.â induced neurodegeneration and the central inflammatory reaction. These data provide evidence that central, chronic IL-1â expression can trigger and systemic IL-1â exacerbate nigral neurodegeneration and highlight the functional relevance of this cytokine in PD.â expression can trigger and systemic IL-1â exacerbate nigral neurodegeneration and highlight the functional relevance of this cytokine in PD.