Antifungal activity and toxicity studies of flavanones isolated from Tessaria dodoneifolia aerial parts

SOBERÓN, J. R.; SGARIGLIA, M. A.; CARABAJAL TORREZ, J.A.; AGUILAR, F.A.; PERO, E.J.; SAMPIETRO, D.A.; DE LUCO, J.F. ; LABADIE, G.

Heliyon

Elsevier BV

Lugar: Ámsterdam; Año: 2020 vol. 6

2405-8440

Tessaria dodoneifolia [Asteraceae] is traditionally employed in Northwestern A rgentina for fungal infections treatrnent. We report the antifungal activity guided isolation and identification of substances from aerial parts of this species, both individually and in combination with fluconazole (FLU), against Gandida alhicans strains. Two antifungal flavanones were identified as naringenin (NAR) and pinocembrin (PIN). These compounds could individually inhibit the growth of C. alhicans strains. Combinations of NAR and PIN with FLU were synergistic against the FLU resistant and sensitive C. alhicans strains. Genotoxic and cytotoxic evaluations were also performed. NAR, PIN and their combinations with FLU did not have a genotoxic effect on Bacilllls subtilis rec strains. Finally, these compounds did not show cytotoxicity at concentrations below 80 μg/mL