Virucidal activity of essential oils from aromatic plants of San Luis, Argentina

C. C. GARCÍA; LAURA B. TALARICO; NORMA ALMEIDA; S. COLOMBRES; CLAUDIA DUSCHATZKY; E. B. DAMONTE

PHYTOTHERAPY RESEARCH

John Wiley and Sons

Lugar: New York; Año: 2003 vol. 17 p. 1073 - 1075

0951-418X

1 Essential oils obtained from eight aromatic plants of San Luis Province, Argentina, were screened for virucidal activity against herpes simplex virus type 1 (HSV-1), Junin virus (JUNV) and dengue virus type 2 (DEN-2). The most potent inhibition was observed with the essential oil of Lippia junelliana and Lippia turbinata against JUNV with virucidal concentration 50% (VC(50)) values in the range 14-20 ppm, whereas Aloysia gratissima, Heterotheca latifolia and Tessaria absinthioides inhibited JUNV in the range 52-90 ppm. The virucidal activity was time- and temperature-dependent. The essential oils of A. gratissima, Artemisia douglasiana, Eupatorium patens and T. absinthioides inactivated HSV-1 at 65-125 ppm. However, only A. douglasiana and E. patens had any discernible effect on DEN-2 infectivity with VC(50) values of 60 and 150 ppm, respectively. Copyright 2003 John Wiley & Sons, Ltd.