INVESTIGADORES
MARIN Maia Solange
artículos
Título:
Toll-like receptor activation and expression in bovine alpha-herpesvirus infections
Autor/es:
MARIN, M.; QUINTANA S; FAVERÍN C; LEUNDA MR; ODEÓN AC; PÉREZ SE
Revista:
RESEARCH IN VETERINARY SCIENCE
Editorial:
ELSEVIER SCI LTD
Referencias:
Lugar: Amsterdam; Año: 2014 vol. 96 p. 196 - 203
ISSN:
0034-5288
Resumen:
The involvement of Toll-like receptors (TLRs) in bovine herpesvirus types 1 (BoHV-1) and 5 (BoHV-5) infections has not been analyzed. In this study, the role of TLR signaling on virus replication was investigated. Blood leukocytes consistently express TLRs. Thus, our approach was to study in vitro the effects of agonist stimulation of TLRs expressed by peripheral blood leukocytes on BoHV-1 and BoHV-5 replication. Furthermore, the patterns of TLRs 3, 7?9 expression on virus-infected-bovine leukocytes were analyzed. Only Imiquimod (TLR7/8 agonist) showed anti-viral activity on infected MDBK cells. This is the first evidence that the timely activation of TLR7/8 signaling is effective in impairing BoHV-1 and 5 replication, thereby providing an experimental indication that Imiquimod may be a promising immune modulator. This work describes, for the first time, the expression patterns of TLRs in BoHV-1- or BoHV-5-infectedbovine leukocytes, suggesting the involvement of TLR7 and TLR9 in the recognition of these viruses.