Are the mechanisms involved in astrocyte and lymphocyte death during HIV infection similar?

OJEDA D.S.; TILL A.; QUARLERI J.

NEURAL REGENERATION RESEARCH

SHENYANG EDITORIAL DEPT NEURAL REGENERATION RES

Año: 2019

1673-5374

Acquired immune de ciency syndrome is associated with the death of CD4+ T lymphocytes. e entry of the human immunode ciency virus (HIV) into the central nervous system leads to a broad spectrum of HIV-associated neurocognitive disorders (HAND) ranging from mild to severe dementia. Inside the central nervous system, HIV establishes infection in astrocytes ? the predominant cell type in the brain, thus causing neuropathology, but the underlying mechanisms remain un- known. Much research has been focused on the role of innate immune activation, prompted by abundance of soluble viral factors, abortive infection, or cytokines secreted by neighboring microglia and associ- ated with neuroin ammation and HAND. However, the mechanisms that prime and activate the in ammatory process during HIV infection have not been unraveled (Rawat et al., 2019).