Depolarization spatial variance as a cardiac dyssynchrony descriptor

BONOMINI MARIA PAULA; DANIEL FELIPE ORTEGA; LUIS DANTE BARJA; NICOLAS MANGANI; ARINI PD

BIOMEDICAL SIGNAL PROCESSING AND CONTROL

ELSEVIER SCI LTD

Lugar: Amsterdam; Año: 2019 vol. 49 p. 540 - 545

1746-8094

Ventricular depolarization dispersion refers mainly to heterogeneity in interlead QRS durations. Here, we propose the spatial variance (SVd) to describe depolarization dispersion about a mean QRS morphology. We hypothesize that waveform changes can be more accurate than interval changes at measuringQRS heterogeneity, and less sensitive to delineation errors. To prove this, SVdwas computed on 36 dyssynchrony patients either in sinus rhythm (SVdB) orunder nHB (SVdHB), and on 32 control subjects with native conduction (SVdN).In the normal ECG, there are interlead sets that produce maximal (SVdNmax)and minimal (SVdNmin) spatial variance. In Baseline patients, SVdB significantlyincreased from controls in the minimal variance situation (p