Synthesis and evaluation of aromatic methoxime derivatives against five postharvest phytopathogenic fungi of fruits. Main structure-activity relationships

CORTÉS, I.; DI LIBERTO, M. G.; KAUFMAN, T. S.; DERITA, M. G.; BRACCA, A. B. J.

FOOD CHEMISTRY

ELSEVIER SCI LTD

Lugar: Amsterdam; Año: 2020

0308-8146

The antifungal activity of a library of twenty-four aromaticmethoximes was examined against five representative postharvest phytopathogenicfungi. The panel included Penicillium digitatum, Penicillium italicum,Rhizopus stolonifer, Botrytis cinerea and Monilinia fructicola,all of which cause relevant economic losses worldwide as a result of affectingharvested fruits. The minimum inhibitory concentrations and minimum fungicidalconcentrations of each compound were defined and the main structure-activityrelationships were determined. Although other congeners were more potent, druglikeliness considerations pointed to the methoxime derived from2,4-dihydroxypropiophenone as the compound with the most suitable profile. Themorphology of the colonies of the fungal strains treated with the methoxime wasexamined microscopically and the compound was also tested in freshly harvestedpeaches and oranges, exhibiting promising control profiles in both fruits,similar to those of the commercial agents Imazalil and Carbendazim.