The role of mitochondria in inflammatory syndromes

VANASCO, VIRGINIA; MARCHINI, TIMOTEO; MAGNANI, NATALIA; VICO, TAMARA; GARCÉS, MARIANA; CÁCERES, LOURDES; GUAGLIANONE, ALEJANDRO; EVELSON, PABLO; ALVAREZ, SILVIA

BIOCELL

INST HISTOL EMBRIOL-CONICET

Lugar: Mendoza; Año: 2016 vol. 40 p. 47 - 50

0327-9545

Several authors have addressed the importance ofmitochondrial function in inflammatory syndromes, as it may play a role in thegenesis of tissue injury. Sepsis and exposition to environmental particles areexamples of inflammatory conditions. Sepsis occurs with an exacerbatedinflammatory response that damages tissue mitochondria and impairs bioenergeticprocesses. One of the current hypotheses for the molecular mechanismsunderlying the complex condition of sepsis is that enhanced NO production andoxidative stress lead to mitochondrial dysfunction, bioenergetic derangementand organ failure. The mechanism of particulate matter-health effects arebelieved to involve inflammation and oxidative stress. Components in particlesthat elicit inflammation have been poorly investigated, although recentresearch points out to the contribution of compositional elements and particlesize. Oxygen metabolism and mitochondrial function appear to be important areasof study in inflammatory conditions for clarifying molecular mechanismsinvolved.