INVESTIGADORES
PRECIADO Maria Victoria
artículos
Título:
Changes in EBV Association Pattern in Pediatric Classic Hodgkin Lymphoma From a Single Institution in Argentina
Autor/es:
DE MATTEO, ELENA; GARCÍA LOMBARDI, MERCEDES; PRECIADO, MARIA V.; CHABAY, PAOLA
Revista:
Frontiers in Oncology
Editorial:
Frintiers
Referencias:
Año: 2019 vol. 9
Resumen:
In classic Hodgkin lymphoma (cHL), Epstein Barr virus (EBV) associationvaries worldwide. Aims: Our aim was to analyze EBV association with pediatric cHL for the last 28 years.Methods: EBV presence was evaluated by EBERs in situ hybridization andLMP1 immunohistochemistry.Results: Until 2008, we found in pediatric cHL a similar percentage of EBV presence to those observed in adult cHL from developed populations. Nevertheless, in the last 8 years, an unexpected difference in cHL EBV association was proven, along with a slight bias of EBV association with the nodular sclerosis (NS) subtype. Concerning histological subtype distribution, even though MC still prevailed in the whole series, those cases diagnosed as NS showed a sustained rise from 1989 until today.Conclusion: Variations of EBV association of cHL related to geography, age, ethnicity,and histological type have been largely described when compared with different world regions, but interestingly, this single-center revised series brought to light the dynamic process behind the evolution of this relationship over time.