"5-HT2a receptor in mPFC influence context-guided retrieval and reconsolidation of object memory in Perirhinal Cortex",

MORICI FACUNDO; MIRANDA MAGDALENA; GALLO FRANCISCO; ZANONI SAAD MARIA BELEN; BEKINSCHTEIN, PEDRO; NOELIA V WEISSTAUB

elife

eLife Sciences Publications, Ltd

Lugar: Cambridge; Año: 2018

2050-084X

Context dependent memories may guide adaptive behavior relaying in previous experience while 16 updating stored information through reconsolidation. Retrieval can be triggered by partial cues, 17 thus, in the presence of shared cues, the most relevant memory should be updated. We explore 18 how this occurs as well as the underlying mechanism. In a contextual version of the object 19 recognition task, we examined the effect of medial PFC (mPFC) serotonin 2a receptor(5-HT2aR) 20 blockade during retrieval in reconsolidation of objects memories. We found that mPFC 5-HT2aR 21 controls retrieval and reconsolidation of object memories in perirhinal cortex (PRH) but not in 22 dorsal hippocampus. Also, context-guided control of reconsolidation in PRH required a functional 23 interaction between the ventral hippocampus and the mPFC. Our results indicate that in the 24 presence of conflicting information at retrieval, mPFC 5-HT2aR facilitates top-down context-guided 25 control over PRH that controls the behavioral response and object memory reconsolidation. 26Key words: Serotonin ? Memory retrieval ? Memory reconsolidation ? Prefrontal Cortex