UMYMFOR   05516
UNIDAD DE MICROANALISIS Y METODOS FISICOS EN QUIMICA ORGANICA
Unidad Ejecutora - UE
artículos
Título:
Chemoenzymatic synthesis of new derivatives of glycyrrhetinic acid with antiviral activity. Molecular docking study?
Autor/es:
ALCHÉ, L.; ZIGOLO, M.A.; BALDESSARI, A.; SALINAS, M.; GARCÍA LIÑARES, G.
Revista:
BIOORGANIC CHEMISTRY
Editorial:
ACADEMIC PRESS INC ELSEVIER SCIENCE
Referencias:
Lugar: Amsterdam; Año: 2018 vol. 78 p. 210 - 219
ISSN:
0045-2068
Resumen:
We present an efficient approach to the synthesis of a series of glycyrrhetinic acid derivatives. Six derivatives,five of them new compounds, were obtained through chemoenzymatic reactions in very good toexcellent yield. In order to find the optimal reaction conditions, the influence of various parameters suchas enzyme source, nucleophile:substrate ratio, enzyme:substrate ratio, solvent and temperature wasstudied. The excellent results obtained by lipase catalysis made the procedure very efficient consideringtheir advantages such as mild reaction conditions and low environmental impact. Moreover, in order toexplain the reactivity of glycyrrhetinic acid and the acetylated derivative to different nucleophiles in theenzymatic reactions, molecular docking studies were carried out. In addition, one of the synthesized compoundsexhibited remarkable antiviral activity against TK + and TK- strains of Herpes simplex virus type1 (HSV-1), sensitive and resistant to acyclovir (ACV) treatment.