PERSONAL DE APOYO
GAUNA Gabriela Alejandra
artículos
Título:
Interaction of cationic phthalocyanines with DNA. Importance of the structure of the substituents
Autor/es:
NOELIA LOPEZ CEBALLOS; GABRIELA GAUNA
Revista:
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
Editorial:
ELSEVIER SCIENCE SA
Referencias:
Lugar: Amsterdam; Año: 2014 p. 29 - 33
ISSN:
1011-1344
Resumen:
The interaction of novel zinc (II) cationic phthalocyanines with CT-DNA was studied using absorption and fluorescencespectroscopy, as well as thermal denaturation profiles. Results showed an electrostatic interactionbetween the phthalocyanines and CT-DNA. The properties of these phthalocyanines were compared takingthe structure of the macrocycle peripheral substituents into account. 2,9(10),16(17),23(24)-tetrakis[(N-butyl-N-methylammonium)ethylsulfanyl]phthalocyaninatozinc(II) tetraiodide (Pc6) had a greateraffinity for the CT-DNA helix than its bioisoster 2,9(10),16(17),23(24)-tetrakis[(N-dibutyl-N-methylammonium)ethoxy]phthalocyaninatozinc(II) tetraiodide (Pc7). 2,9(10),16(17),23(24)-tetrakis[(2-trimethylammonium)ethyl-sulfanyl]phthalocyaninatozinc(II) tetraiodide (Pc13) also carried a sulfur atom likePc6, but linked to bulky substituents such as trimethylammonium groups. The planar aromatic regionof the cationic phthalocyanines in this study appears to be unable to facilitate their intercalation withCT-DNA.
