Whole Cell Biocatalysts for the Preparation of Nucleosides and their Derivatives

LEWKOWICZ, ELIZABETH S.; IRIBARREN, ADOLFO M.

CURRENT PHARMACEUTICAL DESIGN.

BENTHAM SCIENCE PUBL LTD

Año: 2017 vol. 23 p. 6851 - 6878

1381-6128

Nucleosides constitute an extensive group of natural and chemically modified compounds that display a wide range of structures and activities. Different biocatalysts have been developed for their preparation, but the choice of commercially available enzymes is limited. Therefore, the search of new biocatalysts is particularly attractive. In this sense, microorganisms are a vast source of enzymatic diversity that can be directly used as a whole cell biocatalysts providing a potential cheaper and suitable route for industrial applications.