PHARMACOKINETICS AND BIOAVAILABILITY OF CALCIUM FOSFOMYCIN IN POST WEANING PIGLETS AFTER ORAL ADMINISTRATION

PÉREZ, D. S., SORACI A. L., TAPIA M. O

INTERNATIONAL JOURNAL FOR AGRO VETERINARY AND MEDICAL SCIENCES

IJAVMS

Año: 2012 vol. 6 p. 424 - 435

1999-9666

Calcium fosfomycin pharmacokinetics and bioavailability were studied in post weaning piglets after oral administration of 30 mg/kg of body weight. Plasma concentrations were measured by high-performance liquid chromatography MS/MS. The area under the fosfomycin concentration:time curve in plasma AUC(0-12) was of 39.6 ± 9.20 µg h/ml. The T1/2 was of 1.80 ± 0.89 h. Cmax, Tmax and bioavailability were 3.60 ± 0.96 µg/ml, 3.00 ± 0.00 h and 20.0 ± 1.85 %, respectively. Different authors have determined a minimum inhibitory concentration (MIC90) ranging from 0.25 µg/ml for Streptococcus sp. and 0.5 µg/ml for Escherichia coli. According to the values of plasma concentration vs time profiles observed in this study and considering the above facts explained, effective plasma concentrations of fosfomycin for sensitive bacteria can be obtained following oral administration of 30 mg/kg in piglets.