Alteration of serum neural cell adhesion molecule (NCAM) in patients with brain tumors

LAURA TODARO*, PAOLA CAMPODONICO, MIRTA VARELA#, M. GUADALUPE PALLOTA#, JOSÉ LASTIRI#, #, STELLA RANUNCOLO, ANA MORANDI, ELISA BAL DE KIER JOFFÉ*, EUGENIA SACERDOTE DE LUSTIG*, LYDIA PURICELLI*.

Neuro-oncology

Carden Jennings Pub

Lugar: Charlottesville, VA; Año: 2006 p. 1 - 20

1522-8517

NCAM is a membrane glycoprotein, expressed in neuroectodermis, mesenchyma and tumor cells derived from these tissues. N-CAM can also be found in sera, although little is known about its modulation in different pathological states. Objective: to study the expression of serum NCAM in patients with brain tumors [gliomas (n=34), metastasis confined to brain (n=27) and benign tumors (n=22)] compared with non-tumoral controls (n=69). NCAM was measured by Western blot and densitometric quantitative analysis, employing a monoclonal antibody which revealed bands of high (HMW, ³130kDa) and low (LMW,