IIBBA   05544
INSTITUTO DE INVESTIGACIONES BIOQUIMICAS DE BUENOS AIRES
Unidad Ejecutora - UE
artículos
Título:
The more you have, the less you get: the functional role of inflammation on neuronal differentiation of endogenous and transplanted neural stem cells in the adult brain.
Autor/es:
PATRICIA MATHIEU; DANIELA BATTISTA; AMAICHA M DEPINO; VALERIA ROCA; MARIANA GRACIARENA; FERNANDO J. PITOSSI
Revista:
JOURNAL OF NEUROCHEMISTRY
Editorial:
WILEY-BLACKWELL PUBLISHING, INC
Referencias:
Año: 2010 vol. 112 p. 1368 - 1385
ISSN:
0022-3042
Resumen:
The differentiation of neural stem cells toward a neuronal
phenotype is determined by the extracellular and intracellular
factors that form the neurogenic niche. In this review, we
discuss the available data on the functional role of inflammation
and in particular, pro- and anti-inflammatory cytokines,
on neuronal differentiation from endogenous and transplanted
neural stem/progenitor cells. In addition, we discuss the role of
microglial cell activation on these processes and the fact that
microglial cell activation is not univocally associated with a
pro-inflammatory milieu. We conclude that brain cytokines
could be regarded as part of the endogenous neurogenic
niche. In addition, we propose that accumulating evidence
suggests that pro-inflammatory cytokines have a negative
effect on neuronal differentiation, while anti-inflammatory
cytokines exert an opposite effect. The clarification of the
functional role of cytokines on neuronal differentiation will be
relevant not only to better understand adult neurogenesis, but
also to envisage complementary treatments to modulate
cytokine action that could increase the therapeutic benefit of
future progenitor/stem cell-based therapies.
Keywords: cytokines, inflammation, neural stem cell, neuronal
differentiation, Parkinsons disease.
differentiation, Parkinsons disease.
differentiation, Parkinsons disease.
cytokines, inflammation, neural stem cell, neuronal
differentiation, Parkinsons disease.
J. Neurochem. (2010) 112, 13681385.(2010) 112, 13681385.