Nucleoside synthesis using a novel macroporous grafted polyethylene as biocatalyst support

J. TRELLES; L. BENTANCOR; M. GRASSELLI; E LEWKOWICZ; A IRIBARREN

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Elsevier

Año: 2008 p. 189 - 193

1381-1177

Nucleoside analogue synthesis has received much attention because of the wide range of applications that these molecules offer. They areextensively used as antiviral, antitumor and more recently, as starting materials for functional oligonucleotides. Microbial whole cells are efficient,ecological and lowcost biocatalysts that have been successfully applied to the preparation of these compounds.Anewsupport for cell immobilizationthat involves the use of a macroporous polyethylene polymer grafted with chains of polyglycidyl methacrylate?ethylendiamine is described in thispaper. High stability and productivity and easy handling are some of the advantages of the here developed biocatalyst.