INVESTIGADORES
BEKINSCHTEIN Pedro Alejandro
artículos
Título:
The role of apoptosis in the inhibition of a secondary tumor by concomitant resistance in a mouse model of metastases
Autor/es:
MARCELA FRANCO; PEDRO BEKINSCHTEIN; PEDRO DI GIANNI; OSCAR D. BUSTUOABAD; SILVIA VANZULLI; RAUL A. RUGGIERO
Revista:
MEDICINA (BUENOS AIRES)
Referencias:
Año: 1996 vol. 56 p. 393 - 396
ISSN:
0025-7680
Resumen:
Resistance of tumor-bearing mice to a second tumor challenge, that is,
concomitant resistance, was studied using the LB tumor model. In a
secondary LB tumor implant inhibited by concomitant resistance an
increase in the percentage or apoptotic cells and alterations in cell
cycle distribution were observed. Similar alterations were observed in
LB tumor cells incubated with serum from tumor-bearing mice. The data
presented in this paper suggest that apoptosis is one of the mechanisms
involved in tumor dormancy due to concomitant resistance.