INVESTIGADORES
BEKINSCHTEIN Pedro Alejandro
artículos
Título:
Endogenous BDNF is required for long-term memory formation in the rat parietal cortex
Autor/es:
MARIANA ALONSO; PEDRO BEKINSCHTEIN; MARTÍN CAMMAROTA; MONICA R. VIANNA; IVAN IZQUIERDO; JORGE H. MEDINA
Revista:
LEARNING & MEMORY (COLD SPRING HARBOR, N.Y.)
Editorial:
Cold Spring Harbor Laboratory Press
Referencias:
Lugar: Cold Spring Harbour (NY); Año: 2005 vol. 12 p. 504 - 510
ISSN:
1072-0502
Resumen:
Information storage in the brain is a temporally graded process
involving different memory phases as well as different structures in
the mammalian brain. Cortical plasticity seems to be essential to store
stable long-term memories, although little information is available at
the moment regarding molecular and cellular events supporting memory
consolidation in the neocortex. Brain-derived neurotrophic factor
(BDNF) modulates both short-term synaptic function and
activity-dependent synaptic plasticity in hippocampal and cortical
neurons. We have recently demonstrated that endogenous BDNF in the
hippocampus is involved in memory formation. Here we examined the role
of BDNF in the parietal cortex (PCx) in short-term (STM) and long-term
memory (LTM) formation of a one-trial fear-motivated learning task in
rats. Bilateral infusions of function-blocking anti-BDNF antibody into
the PCx impaired both STM and LTM retention scores and decreased the
phosphorylation state of cAMP response element-binding protein (CREB).
In contrast, intracortical administration of recombinant human BDNF
facilitated LTM and increased CREB activation. Moreover, inhibitory
avoidance training is associated with a rapid and transient increase in
phospho-CREB/total CREB ratio in the PCx. Thus, our results indicate
that endogenous BDNF is required for both STM and LTM formation of
inhibitory avoidance learning, possibly involving CREB
activation-dependent mechanisms. The present data support the idea that
early sensory areas constitute important components of the networks
subserving memory formation and that information processing in
neocortex plays an important role in memory formation.