INVESTIGADORES
BEKINSCHTEIN Pedro Alejandro
artículos
Título:
Persistence of long-term memory storage requires a late protein synthesis- and BDNF-dependent phase in the hippocampus
Autor/es:
PEDRO BEKINSCHTEIN; MARTÍN CAMMAROTA; LIONEL MÜLLER IGAZ; LIA R. BEVILACQUA; IVAN IZQUIERDO; JORGE H. MEDINA
Revista:
NEURON
Editorial:
Cell Press
Referencias:
Lugar: Cambridge. Massachusets; Año: 2007 vol. 53 p. 261 - 277
ISSN:
0896-6273
Resumen:
Persistence is the most characteristic attribute of long-term memory
(LTM). To understand LTM, we must understand how memory traces persist
over time despite the short-lived nature and rapid turnover of their
molecular substrates. It is widely accepted that LTM formation is
dependent upon hippocampal de novo protein synthesis and Brain-Derived
Neurotrophic Factor (BDNF) signaling during or early after acquisition.
Here we show that 12 hr after acquisition of a one-trial associative
learning task, there is a novel protein synthesis and BDNF-dependent
phase in the rat hippocampus that is critical for the persistence of
LTM storage. Our findings indicate that a delayed stabilization phase
is specifically required for maintenance, but not formation, of the
memory trace. We propose that memory formation and memory persistence
share some of the same molecular mechanisms and that recurrent rounds
of consolidation-like events take place in the hippocampus for
maintenance of the memory trace.