IIBBA   05544
INSTITUTO DE INVESTIGACIONES BIOQUIMICAS DE BUENOS AIRES
Unidad Ejecutora - UE
artículos
Título:
The enzyme NBAD-synthase plays diverse roles during the life cycle of
Autor/es:
PEREZ, MARTIN MARIANO; SCHACHTER, JULIETA; BERNI, JIMENA; QUESADA-ALLUE, LUIS ALBERTO
Revista:
JOURNAL OF INSECT PHYSIOLOGY
Editorial:
Elsevier
Referencias:
Año: 2009 vol. 56 p. 8 - 13
ISSN:
0022-1910
Resumen:
This report shows the biochemical characterization and life cycle-dependent expression of Drosophila
melanogaster N-b-alanyldopamine synthase (NBAD-synthase or Ebony protein). This enzyme not only
catalyzes the synthesis of NBAD, the main sclerotization and pigmentation precursor of insect brown
cuticles, but also plays a role in brain neurotransmitter metabolism. In addition to the epidermis
expression our immunodetection experiments show the novel localization of NBAD-synthase in
different regions of the adult brain, in the foregut of pharate adult and, surprisingly, in the epidermis of
the trachea during embryogenesis. These results demonstrate that NBAD-synthase is a versatile enzyme
involved in different, previously unknown, time- and tissue-dependent processes.
catalyzes the synthesis of NBAD, the main sclerotization and pigmentation precursor of insect brown
cuticles, but also plays a role in brain neurotransmitter metabolism. In addition to the epidermis
expression our immunodetection experiments show the novel localization of NBAD-synthase in
different regions of the adult brain, in the foregut of pharate adult and, surprisingly, in the epidermis of
the trachea during embryogenesis. These results demonstrate that NBAD-synthase is a versatile enzyme
involved in different, previously unknown, time- and tissue-dependent processes.
catalyzes the synthesis of NBAD, the main sclerotization and pigmentation precursor of insect brown
cuticles, but also plays a role in brain neurotransmitter metabolism. In addition to the epidermis
expression our immunodetection experiments show the novel localization of NBAD-synthase in
different regions of the adult brain, in the foregut of pharate adult and, surprisingly, in the epidermis of
the trachea during embryogenesis. These results demonstrate that NBAD-synthase is a versatile enzyme
involved in different, previously unknown, time- and tissue-dependent processes.
catalyzes the synthesis of NBAD, the main sclerotization and pigmentation precursor of insect brown
cuticles, but also plays a role in brain neurotransmitter metabolism. In addition to the epidermis
expression our immunodetection experiments show the novel localization of NBAD-synthase in
different regions of the adult brain, in the foregut of pharate adult and, surprisingly, in the epidermis of
the trachea during embryogenesis. These results demonstrate that NBAD-synthase is a versatile enzyme
involved in different, previously unknown, time- and tissue-dependent processes.
catalyzes the synthesis of NBAD, the main sclerotization and pigmentation precursor of insect brown
cuticles, but also plays a role in brain neurotransmitter metabolism. In addition to the epidermis
expression our immunodetection experiments show the novel localization of NBAD-synthase in
different regions of the adult brain, in the foregut of pharate adult and, surprisingly, in the epidermis of
the trachea during embryogenesis. These results demonstrate that NBAD-synthase is a versatile enzyme
involved in different, previously unknown, time- and tissue-dependent processes.
melanogaster N-b-alanyldopamine synthase (NBAD-synthase or Ebony protein). This enzyme not only
catalyzes the synthesis of NBAD, the main sclerotization and pigmentation precursor of insect brown
cuticles, but also plays a role in brain neurotransmitter metabolism. In addition to the epidermis
expression our immunodetection experiments show the novel localization of NBAD-synthase in
different regions of the adult brain, in the foregut of pharate adult and, surprisingly, in the epidermis of
the trachea during embryogenesis. These results demonstrate that NBAD-synthase is a versatile enzyme
involved in different, previously unknown, time- and tissue-dependent processes.
catalyzes the synthesis of NBAD, the main sclerotization and pigmentation precursor of insect brown
cuticles, but also plays a role in brain neurotransmitter metabolism. In addition to the epidermis
expression our immunodetection experiments show the novel localization of NBAD-synthase in
different regions of the adult brain, in the foregut of pharate adult and, surprisingly, in the epidermis of
the trachea during embryogenesis. These results demonstrate that NBAD-synthase is a versatile enzyme
involved in different, previously unknown, time- and tissue-dependent processes.
catalyzes the synthesis of NBAD, the main sclerotization and pigmentation precursor of insect brown
cuticles, but also plays a role in brain neurotransmitter metabolism. In addition to the epidermis
expression our immunodetection experiments show the novel localization of NBAD-synthase in
different regions of the adult brain, in the foregut of pharate adult and, surprisingly, in the epidermis of
the trachea during embryogenesis. These results demonstrate that NBAD-synthase is a versatile enzyme
involved in different, previously unknown, time- and tissue-dependent processes.
catalyzes the synthesis of NBAD, the main sclerotization and pigmentation precursor of insect brown
cuticles, but also plays a role in brain neurotransmitter metabolism. In addition to the epidermis
expression our immunodetection experiments show the novel localization of NBAD-synthase in
different regions of the adult brain, in the foregut of pharate adult and, surprisingly, in the epidermis of
the trachea during embryogenesis. These results demonstrate that NBAD-synthase is a versatile enzyme
involved in different, previously unknown, time- and tissue-dependent processes.
catalyzes the synthesis of NBAD, the main sclerotization and pigmentation precursor of insect brown
cuticles, but also plays a role in brain neurotransmitter metabolism. In addition to the epidermis
expression our immunodetection experiments show the novel localization of NBAD-synthase in
different regions of the adult brain, in the foregut of pharate adult and, surprisingly, in the epidermis of
the trachea during embryogenesis. These results demonstrate that NBAD-synthase is a versatile enzyme
involved in different, previously unknown, time- and tissue-dependent processes.
melanogaster N-b-alanyldopamine synthase (NBAD-synthase or Ebony protein). This enzyme not only
catalyzes the synthesis of NBAD, the main sclerotization and pigmentation precursor of insect brown
cuticles, but also plays a role in brain neurotransmitter metabolism. In addition to the epidermis
expression our immunodetection experiments show the novel localization of NBAD-synthase in
different regions of the adult brain, in the foregut of pharate adult and, surprisingly, in the epidermis of
the trachea during embryogenesis. These results demonstrate that NBAD-synthase is a versatile enzyme
involved in different, previously unknown, time- and tissue-dependent processes.
catalyzes the synthesis of NBAD, the main sclerotization and pigmentation precursor of insect brown
cuticles, but also plays a role in brain neurotransmitter metabolism. In addition to the epidermis
expression our immunodetection experiments show the novel localization of NBAD-synthase in
different regions of the adult brain, in the foregut of pharate adult and, surprisingly, in the epidermis of
the trachea during embryogenesis. These results demonstrate that NBAD-synthase is a versatile enzyme
involved in different, previously unknown, time- and tissue-dependent processes.
catalyzes the synthesis of NBAD, the main sclerotization and pigmentation precursor of insect brown
cuticles, but also plays a role in brain neurotransmitter metabolism. In addition to the epidermis
expression our immunodetection experiments show the novel localization of NBAD-synthase in
different regions of the adult brain, in the foregut of pharate adult and, surprisingly, in the epidermis of
the trachea during embryogenesis. These results demonstrate that NBAD-synthase is a versatile enzyme
involved in different, previously unknown, time- and tissue-dependent processes.
catalyzes the synthesis of NBAD, the main sclerotization and pigmentation precursor of insect brown
cuticles, but also plays a role in brain neurotransmitter metabolism. In addition to the epidermis
expression our immunodetection experiments show the novel localization of NBAD-synthase in
different regions of the adult brain, in the foregut of pharate adult and, surprisingly, in the epidermis of
the trachea during embryogenesis. These results demonstrate that NBAD-synthase is a versatile enzyme
involved in different, previously unknown, time- and tissue-dependent processes.
catalyzes the synthesis of NBAD, the main sclerotization and pigmentation precursor of insect brown
cuticles, but also plays a role in brain neurotransmitter metabolism. In addition to the epidermis
expression our immunodetection experiments show the novel localization of NBAD-synthase in
different regions of the adult brain, in the foregut of pharate adult and, surprisingly, in the epidermis of
the trachea during embryogenesis. These results demonstrate that NBAD-synthase is a versatile enzyme
involved in different, previously unknown, time- and tissue-dependent processes.
melanogaster N-b-alanyldopamine synthase (NBAD-synthase or Ebony protein). This enzyme not only
catalyzes the synthesis of NBAD, the main sclerotization and pigmentation precursor of insect brown
cuticles, but also plays a role in brain neurotransmitter metabolism. In addition to the epidermis
expression our immunodetection experiments show the novel localization of NBAD-synthase in
different regions of the adult brain, in the foregut of pharate adult and, surprisingly, in the epidermis of
the trachea during embryogenesis. These results demonstrate that NBAD-synthase is a versatile enzyme
involved in different, previously unknown, time- and tissue-dependent processes.
catalyzes the synthesis of NBAD, the main sclerotization and pigmentation precursor of insect brown
cuticles, but also plays a role in brain neurotransmitter metabolism. In addition to the epidermis
expression our immunodetection experiments show the novel localization of NBAD-synthase in
different regions of the adult brain, in the foregut of pharate adult and, surprisingly, in the epidermis of
the trachea during embryogenesis. These results demonstrate that NBAD-synthase is a versatile enzyme
involved in different, previously unknown, time- and tissue-dependent processes.
catalyzes the synthesis of NBAD, the main sclerotization and pigmentation precursor of insect brown
cuticles, but also plays a role in brain neurotransmitter metabolism. In addition to the epidermis
expression our immunodetection experiments show the novel localization of NBAD-synthase in
different regions of the adult brain, in the foregut of pharate adult and, surprisingly, in the epidermis of
the trachea during embryogenesis. These results demonstrate that NBAD-synthase is a versatile enzyme
involved in different, previously unknown, time- and tissue-dependent processes.
catalyzes the synthesis of NBAD, the main sclerotization and pigmentation precursor of insect brown
cuticles, but also plays a role in brain neurotransmitter metabolism. In addition to the epidermis
expression our immunodetection experiments show the novel localization of NBAD-synthase in
different regions of the adult brain, in the foregut of pharate adult and, surprisingly, in the epidermis of
the trachea during embryogenesis. These results demonstrate that NBAD-synthase is a versatile enzyme
involved in different, previously unknown, time- and tissue-dependent processes.
catalyzes the synthesis of NBAD, the main sclerotization and pigmentation precursor of insect brown
cuticles, but also plays a role in brain neurotransmitter metabolism. In addition to the epidermis
expression our immunodetection experiments show the novel localization of NBAD-synthase in
different regions of the adult brain, in the foregut of pharate adult and, surprisingly, in the epidermis of
the trachea during embryogenesis. These results demonstrate that NBAD-synthase is a versatile enzyme
involved in different, previously unknown, time- and tissue-dependent processes.
melanogaster N-b-alanyldopamine synthase (NBAD-synthase or Ebony protein). This enzyme not only
catalyzes the synthesis of NBAD, the main sclerotization and pigmentation precursor of insect brown
cuticles, but also plays a role in brain neurotransmitter metabolism. In addition to the epidermis
expression our immunodetection experiments show the novel localization of NBAD-synthase in
different regions of the adult brain, in the foregut of pharate adult and, surprisingly, in the epidermis of
the trachea during embryogenesis. These results demonstrate that NBAD-synthase is a versatile enzyme
involved in different, previously unknown, time- and tissue-dependent processes.
catalyzes the synthesis of NBAD, the main sclerotization and pigmentation precursor of insect brown
cuticles, but also plays a role in brain neurotransmitter metabolism. In addition to the epidermis
expression our immunodetection experiments show the novel localization of NBAD-synthase in
different regions of the adult brain, in the foregut of pharate adult and, surprisingly, in the epidermis of
the trachea during embryogenesis. These results demonstrate that NBAD-synthase is a versatile enzyme
involved in different, previously unknown, time- and tissue-dependent processes.
catalyzes the synthesis of NBAD, the main sclerotization and pigmentation precursor of insect brown
cuticles, but also plays a role in brain neurotransmitter metabolism. In addition to the epidermis
expression our immunodetection experiments show the novel localization of NBAD-synthase in
different regions of the adult brain, in the foregut of pharate adult and, surprisingly, in the epidermis of
the trachea during embryogenesis. These results demonstrate that NBAD-synthase is a versatile enzyme
involved in different, previously unknown, time- and tissue-dependent processes.
catalyzes the synthesis of NBAD, the main sclerotization and pigmentation precursor of insect brown
cuticles, but also plays a role in brain neurotransmitter metabolism. In addition to the epidermis
expression our immunodetection experiments show the novel localization of NBAD-synthase in
different regions of the adult brain, in the foregut of pharate adult and, surprisingly, in the epidermis of
the trachea during embryogenesis. These results demonstrate that NBAD-synthase is a versatile enzyme
involved in different, previously unknown, time- and tissue-dependent processes.
catalyzes the synthesis of NBAD, the main sclerotization and pigmentation precursor of insect brown
cuticles, but also plays a role in brain neurotransmitter metabolism. In addition to the epidermis
expression our immunodetection experiments show the novel localization of NBAD-synthase in
different regions of the adult brain, in the foregut of pharate adult and, surprisingly, in the epidermis of
the trachea during embryogenesis. These results demonstrate that NBAD-synthase is a versatile enzyme
involved in different, previously unknown, time- and tissue-dependent processes.
Drosophila
melanogaster N-b-alanyldopamine synthase (NBAD-synthase or Ebony protein). This enzyme not only
catalyzes the synthesis of NBAD, the main sclerotization and pigmentation precursor of insect brown
cuticles, but also plays a role in brain neurotransmitter metabolism. In addition to the epidermis
expression our immunodetection experiments show the novel localization of NBAD-synthase in
different regions of the adult brain, in the foregut of pharate adult and, surprisingly, in the epidermis of
the trachea during embryogenesis. These results demonstrate that NBAD-synthase is a versatile enzyme
involved in different, previously unknown, time- and tissue-dependent processes.
catalyzes the synthesis of NBAD, the main sclerotization and pigmentation precursor of insect brown
cuticles, but also plays a role in brain neurotransmitter metabolism. In addition to the epidermis
expression our immunodetection experiments show the novel localization of NBAD-synthase in
different regions of the adult brain, in the foregut of pharate adult and, surprisingly, in the epidermis of
the trachea during embryogenesis. These results demonstrate that NBAD-synthase is a versatile enzyme
involved in different, previously unknown, time- and tissue-dependent processes.
catalyzes the synthesis of NBAD, the main sclerotization and pigmentation precursor of insect brown
cuticles, but also plays a role in brain neurotransmitter metabolism. In addition to the epidermis
expression our immunodetection experiments show the novel localization of NBAD-synthase in
different regions of the adult brain, in the foregut of pharate adult and, surprisingly, in the epidermis of
the trachea during embryogenesis. These results demonstrate that NBAD-synthase is a versatile enzyme
involved in different, previously unknown, time- and tissue-dependent processes.
catalyzes the synthesis of NBAD, the main sclerotization and pigmentation precursor of insect brown
cuticles, but also plays a role in brain neurotransmitter metabolism. In addition to the epidermis
expression our immunodetection experiments show the novel localization of NBAD-synthase in
different regions of the adult brain, in the foregut of pharate adult and, surprisingly, in the epidermis of
the trachea during embryogenesis. These results demonstrate that NBAD-synthase is a versatile enzyme
involved in different, previously unknown, time- and tissue-dependent processes.
catalyzes the synthesis of NBAD, the main sclerotization and pigmentation precursor of insect brown
cuticles, but also plays a role in brain neurotransmitter metabolism. In addition to the epidermis
expression our immunodetection experiments show the novel localization of NBAD-synthase in
different regions of the adult brain, in the foregut of pharate adult and, surprisingly, in the epidermis of
the trachea during embryogenesis. These results demonstrate that NBAD-synthase is a versatile enzyme
involved in different, previously unknown, time- and tissue-dependent processes.
N-b-alanyldopamine synthase (NBAD-synthase or Ebony protein). This enzyme not only
catalyzes the synthesis of NBAD, the main sclerotization and pigmentation precursor of insect brown
cuticles, but also plays a role in brain neurotransmitter metabolism. In addition to the epidermis
expression our immunodetection experiments show the novel localization of NBAD-synthase in
different regions of the adult brain, in the foregut of pharate adult and, surprisingly, in the epidermis of
the trachea during embryogenesis. These results demonstrate that NBAD-synthase is a versatile enzyme
involved in different, previously unknown, time- and tissue-dependent processes.