INVESTIGADORES
GRAVIELLE Maria Clara
artículos
Título:
Role of allopregnanolone on cerebellar granule cells neurogenesis
Autor/es:
KELLER, ELIZABETH; ZAMPARINI, ANDREA; BORODINSKI, LAURA; MARIA CLARA GRAVIELLE; FISZMAN, MONICA LIDIA
Revista:
DEVELOPMENTAL BRAIN RESEARCH
Editorial:
Elsevier Science Publishers
Referencias:
Año: 2004 vol. 153 p. 13 - 17
ISSN:
0165-3806
Resumen:
The role of allopregnanolone on immature cerebellar granule cells (CGC)proliferation was studied. Allopregnanolone (0.1-1 microM) increased[(3)H]thymidine incorporation and cell number determined by neuronal counting andby an MTT colorimetric assay. The effect of the neurosteroid was completelyprevented by preincubation with 10 mM MgCl(2), 10 microM nifedipine, 10 microMpicrotoxin or by 50 microM bicuculine. We conclude that ALLO affects cerebellarneurogenesis by increasing calcium influx through voltage-gated calcium channels and GABA(A) receptors activation.
