DEVELOPMENT OF A MECHANISM AND AN ACCURATE AND SIMPLE MATHEMATICAL MODEL FOR THE DESCRIPTION OF DRUG RELEASE: APPLICATION TO A RELEVANT EXAMPLE OF ACETAZOLAMIDE-CONTROLLED RELEASE FROM A BIO-INSPIRED ELASTIN BASED HYDROGEL

FERNANDEZ ALICIA; BERMUDEZ JOSE; ARIAS JAVIER; QUINTEROS DANIELA; GONZO ELIO

MATERIALS SCIENCE & ENGINEERING. C, BIOMIMETIC MATERIALS, SENSORS AND SYSTEMS

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2016

0928-4931

Transversality between mathematical modeling, pharmacology, andmaterials science is essential in order to achieve controlled-releasesystems with advanced properties. In this regard, the area ofbiomaterials provides a platform for the development of depots that areable to achieve controlled release of a drug, whereas pharmacologystrives to find new therapeutic molecules and mathematical models have aconnecting function, providing a rational understanding by modeling theparameters that influence the release observed. Herein we present amechanism which, based on reasonable assumptions, explains theexperimental data obtained very well. In addition, we have developed asimple and accurate "lumped" kinetics model to correctly fit theexperimentally observed drug-release behavior. This lumped model allowsus to have simple analytic solutions for the mass and rate of drugrelease as a function of time without limitations of time or mass of drugreleased, which represents an important step-forward in the area of invitro drug delivery when compared to the current state of the art inmathematical modeling. As an example, we applied the mechanism and modelto the release data for acetazolamide from a recombinant polymer. Bothmaterials were selected because of a need to develop a suitableophthalmic formulation for the treatment of glaucoma. The in vitrorelease model proposed herein provides a valuable predictive tool forensuring product performance and batch-to-batch reproducibility, thuspaving the way for the development of further pharmaceutical devices.