IIBBA   05544
INSTITUTO DE INVESTIGACIONES BIOQUIMICAS DE BUENOS AIRES
Unidad Ejecutora - UE
artículos
Título:
Nigral neurodegeneration triggered by striatal AdIL-1 administration can be exacerbated by systemic IL-1 expression
Autor/es:
POTT GODOY M C; FERRARI, CC; PITOSSI, FJ
Revista:
JOURNAL OF NEUROIMMUNOLOGY
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2010
ISSN:
0165-5728
Resumen:
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Neuroinflammation has been proposed
as an important component of Parkinson `s Disease (PD)
aetiology and/or progression.. However, the inflammatory components and the mechanisms
underlying their effects are only partially known. By injecting an adenovirus expressing IL-1 in
the striatum, we provoked progressive neurodegeneration of dopaminergic cells
in the substantia nigra, motor symptoms and microglial activation. All these
effects were attenuated by an anti-inflammatory treatment. Interestingly,
peripheral inflammatory stimuli exacerbated IL-1b induced
neurodegeneration and the central inflammatory reaction.
These data provide evidence that central,
chronic IL-1b expression can trigger and systemic
IL-1 b exacerbate nigral neurodegeneration
and highlight the functional relevance of this cytokine in PD.
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