INVESTIGADORES
SCHINDER Alejandro Fabian
artículos
Título:
The Timing of Neuronal Development in Adult Hippocampal Neurogenesis
Autor/es:
VERÓNICA C. PIATTI; M. SOLEDAD ESPÓSITO; ALEJANDRO F. SCHINDER
Revista:
NEUROSCIENTIST
Referencias:
Año: 2006 vol. 12 p. 463 - 468
ISSN:
1073-8584
Resumen:
The granule cell layer (GCL) of the adult dentate gyrus (DG) is a heterogeneous structure formed by neurons
of different ages because a significant proportion of neurons continues to be generated throughout life. The
subgranular zone of the DG contains neural progenitor cells (NPCs) that divide, differentiate, and migrate to
produce functional dentate granule cells (DGCs) that become incorporated into the existing hippocampal
circuitry. New available tools to identify adult-born neurons in live and fixed brain sections have allowed the
transition from NPC to functional neuron to be characterized in great detail. Maturation of the neuronal
phenotype includes changes in membrane excitability and morphology as well as the establishment of appropriate
connectivity within the existing circuits, a process that lasts several weeks. The events leading to
neuronal maturation share many of the features of the developing brain, and electrical activity is emerging
as a key modulator of neuronal development in the adult DG. The underlying mechanisms are now beginning
to be understood.