LEPTIN ACTION IN NORMAL AND PATHOLOGICAL PREGNANCIES

TORO, AYELÉN R; PEREZ PEREZ, ANTONIO; VILARINO GARCIA,TERESA; MAYMÓ, JULIETA; GUADIX, PILAR; DUEÑAS, JOSE; FERNANDEZ-SANCHEZ, MANUEL; VARONE, CECILIA; SANCHEZ-MARGALET, VICTOR

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (PRINT)

WILEY-BLACKWELL PUBLISHING, INC

Lugar: Londres; Año: 2017

1582-1838

PRIMERA AUTORIA COMPARTIDA CON PEREZ-PEREZ, ANTONIO.Leptin is now considered an important signaling molecule of the reproductive system, since it regulates the production of gonadotropins, the blastocyst formation and implantation, the normal placentation, as well as the feto-placental communication. Leptin is a peptide hormone secreted mainly by adipose tissue and the placenta is the second leptin producing tissue in humans. Placental leptin is an important cytokine which regulates placental functions in an autocrine or paracrine manner. Leptin seems to play a crucial role during the first stages of pregnancy as it modulates critical processes like proliferation, protein synthesis, invasion and apoptosis in placental cells. Furthermore, deregulation of leptin levels has been correlated with the pathogenesis of various disorders associated with reproduction and gestation, including polycystic ovary syndrome, recurrent miscarriage, gestational diabetes mellitus, pre-eclampsia and intrauterine growth restriction. Due to the relevant incidence of the mentioned diseases and the importance of leptin, we decided to review the latest information available about leptin action in normal and pathological pregnancies to support the idea of leptin as an important factor and/or predictor of diverse disorders associated with reproduction and pregnancy.