INVESTIGADORES
GARCIA Guillermo Manuel
artículos
Título:
Novel FKS Mutations Associated with Echinocandin Resistance in Candida Species.
Autor/es:
GARCIA-EFFRON, GUILLERMO; CHUA, DANIEL JOSEPH; TOMADA, JON RUPERT; DIPERSIO, JOSEPH; PERLIN, DAVID S.; GHANNOUM, MAHMOUD; BONILLA, HECTOR
Revista:
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Editorial:
AMER SOC MICROBIOLOGY
Referencias:
Lugar: Washington; Año: 2010 p. 2225 - 2227
ISSN:
0066-4804
Resumen:
We studied three clinical isolates of Candida spp. (1 C. tropicalis and 2 C. glabrata ) isolated from patients with invasive candidiasis. The first isolate emerged during echinocandin treatment while the others after the same treatment. These strains harbored an amino acid substitution in Fksp never linked before with reduced echinocandin susceptibility in C. tropicalis or in C. glabrata. The molecular mechanism of reduced susceptibility was confirmed using a 1,3--D-glucan synthase inhibition assay.
