Cytokines and Genes in Pituitary Tumorigenesis: RSUME Role in Cell Biology

FUERTES, M.; GEREZ, J.A.; HAEDO, M.R.; GIACOMINI, D.; PAEZ-PEREDA, M.; LABEUR, M.; STALLA, G.K.; ARZT, E.

FRONTIERS OF HORMONE RESEARCH.

KARGER

Lugar: Basel; Año: 2010 vol. 38 p. 1 - 6

0301-3073

Cytokines of the IL-6 or gp130 family regulate many cellular responses and play regulatory roles innumerous tissues, and are placed as auto-paracrine regulators of pituitary function acting in normaland tumoral anterior pituitary cells. Especially, IL-6 has a regulatory role in the hormone secretion andgrowth of the anterior pituitary and is involved in adenoma pathogenesis. Recently, IL-6 has beenshown to mediate oncogene-induced senescence (OIS). IL-6 might participate in such a process inadenomas pituitary as well. From pituitary tumoral gp130 overexpressing cells, an unknown protein,RSUME, has been cloned. RSUME is induced by hypoxia in pituitary tumors and regulate pathwaysinvolved in angiogenic and tumorigenic processes (NF-kB/IkB and HIF-1alpha pathways). Thus, it couldhave an important role in the development of the pituitary tumors.