INVESTIGADORES
DIB Nahir Del Valle
artículos
Título:
Evaluation of different PAMAM dendrimers as molecular vehicle of 1,2,4-triazine N-oxide derivative with potential antitumor activity
Autor/es:
NAHIR DIB; LUCIANA FERNÁNDEZ; MERCEDES GONZALEZ; HUGO CERECETTO; EDGARDO DURANTINI; LUIS OTERO; MARISA SANTO
Revista:
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
Editorial:
SPRINGER
Referencias:
Lugar: Berlin; Año: 2014 vol. 79 p. 65 - 73
ISSN:
0923-0750
Resumen:
The interaction between a 1,2,4-triazine N-oxide derivative, that holds potential antitumor activity under hypoxic conditions, and diverse polyamidoamine (PAMAM) dendrimers were investigated with the purpose of select the most appropriate macromolecule to act as potential molecular carrier of this active compound. The results shows that dendrimers with amine terminal groups (PAMAM-AT G = 3) and dendrimers with carboxylate terminal groups (PAMAM-CT G2.5 and G4.5) produces triazine derivative hydrolysis, even in buffered medium, and are not suitable as carriers. In contrast, dendrimers with neutral end groups (PAMAM-OHT) shows stable association with the active compound, making this dendrimer a possible medium for triazine carriage.
