The effect of Midazolam and Propranolol on fear memory reconsolidation in ethanol-withdrawn rats: influence of d-cycloserine

ORTIZ, VANESA; GIACHERO, MARCELO; ESPEJO, PABLO J.AVIER; MOLINA, VÍCTOR ALEJANDRO; MARTIJENA, IRENE D.ELIA

The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)

Oxford Academic

Año: 2015 vol. 18

BACKGROUND: Withdrawal from chronic ethanol facilitates the formation of contextual fear memory and delays the onset to extinction, with its retrieval promoting an increase in ethanol consumption. Consequently, manipulations aimed to reduce these aversive memories, may be beneficial in the treatment of alcohol discontinuation symptoms. Related to this, pharmacological memory reconsolidation blockade has received greater attention due to its therapeutic potential.