Treatment of canine pyometra with the gonadotropin-releasing hormone antagonist acyline: a case series

BATISTA PR; BLANCO PG; GOBELLO C

TOPICS IN COMPANION ANIMAL MEDICINE

W B SAUNDERS CO-ELSEVIER INC

Lugar: Philadelphia; Año: 2015 vol. 30 p. 25 - 27

1938-9736

To describe the effect of the third generation GnRH antagonist acyline in the treatment of four diestrous bitches with the cystic endometrial hyperplasia-pyometra complex (CEH-P). The four bitches were treated with acyline 330 ug/kg SQ on day 0 and antibiotics, and followed for 2 weeks. One closed-cervix case showed cervical dilatation 36 hours after treatment, and the four animals showed resolution of clinical signs starting on day 3 post-treatment. Ultrasonographic uterine diameters and luminal contents decreased to normal size in the bitches having high progesterone serum concentrations before treatment, but not in the female with low levels. Serum progesterone importantly decreased from high to basal concentrations in the three ultrasonographically cured animals. No local or systemic side effects related to the treatment were observed. The GnRH antagonist acyline may have a promising place for the medical treatment of CEH-P complex in the dog.