FOSFOMYCIN CONCENTRATIONS IN EPITHELIAL LINING FLUID IN WEANING PIGLETS

SORACI A. L., PÉREZ, D. S., MARTÍNEZ, G. AMANTO F., TAPIA M. O., DIEGUEZ S.N., FERNÁNDEZ PAGGI M.B.

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS

WILEY-BLACKWELL PUBLISHING, INC

Lugar: Hoboken, New Jersey; Año: 2012 vol. 35 p. 406 - 409

0140-7783

Concentrations of fosfomycin into the epithelial lining fluid (ELF) were studied by bronchoalveolar lavage (BAL) on 6 healthy weaning piglets after the administration of disodium fosfomycin 15 mg/kg intramuscularly (IM). The mean concentrations of fosfomycin in ELF were lower than those in plasma at all sampling time points. Fosfomycin concentrations in ELF were 12.1 % of those in serum. The degree of penetration of fosfomycin into the ELF was determined by comparing the AUC0-8 in ELF with the AUC0-8 in serum. The ratio AUCELF/AUCserum was 0.15 ± 0.02. The Cmax in serum and in ELF were 45.00 ± 2.51 and 3.10 ± 0.95 µg/ml, respectively. These concentrations were achieved at different times (Tmax in serum and ELF: 1.00 ± 0.00 and 2.58 ± 0.49 h, respectively). Effective bacterial killing can be expected from the first antibiotic dosage when the pathogen's MIC is covered for at least 60-70% of the dosing interval. Different authors have determined a fosfomycin MIC90 for Streptococcus sp (important respiratory pathogens in piglets) of 0.25 µg/ml. Fosfomycin concentrations in ELF remained above the MIC90 value for Streptococcus during more than 8 h post IM administration of 15 mg/kg in weaning piglets. However, additional studies should be carried out in the lungs of infected pigs.