Propylparaben applied after pilocarpine-induced status epilepticus modifies hippocampal excitability and glutamate release in rats

CESAR EMMANUEL SANTANA-GÓMEZ; SANDRA A. OROZCO-SUÁREZ; ALAN TALEVI; LUIS E. BRUNO-BLANCH; VÍCTOR MANUEL MAGDALENO-MADRIGAL; RODRIGO FERNÁNDEZ-MÁS; LUISA L. ROCHA ARRIETA

NEUROTOXICOLOGY

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2017 vol. 59 p. 110 - 120

0161-813X

Propylparaben (PPB) induces cardioprotection after ischemia-reperfusioninjury by inhibiting voltage-dependent Na+ channels. The present study focuses on investigating whether the i.p. application of 178 mg/kg PPB after pilocarpineinduced status epilepticus (SE) reduces the acute and long-term consequences of seizure activity. Initially, we investigated the effects of a single administration of PPB after SE. Our results revealed that compared to rats receiving diazepam (DZP) plus vehicle after 2 h of SE, animals receiving a single dose of PPB 1 h after DZP injection presented 126% (p