Anticonvulsant effect of Sodium cyclamate and propylparaben on PTZ-induced seizures in zebrafish

ANTONELLA PISERA FUSTER; SOFÍA OTERO; ALAN TALEVI; LUIS E. BRUNO-BLANCH; RAMÓN BERNABEU

SYNAPSE

WILEY-LISS, DIV JOHN WILEY & SONS INC

Lugar: New York; Año: 2017 vol. 71

0887-4476

Screening for novel anticonvulsant drugs requires appropriate animal seizure models. Zebrafish provide small, accessible and cost-efficient preclinical models applicable to high-throughput small molecule screening. Based in previous results in rodents, we have here examined the effects of artificial sweetener sodium cyclamate and antimicrobial agent sodium propylparaben on a model of PTZ-induced seizures in zebrafish. Sodium cyclamate reduced the bursts of hyperactivity, the spasms, increased the latency to spasms and the latency to seizure, while propylparaben increased the latency to spasms. The results show the potential of zebrafish to detect novel anticonvulsant compounds while they also demonstrate the ability of two commonly ingested chemical compounds to modify the seizure threshold when were administrated at low concentration.