INVESTIGADORES
MARDIROSIAN Mariana Noelia
artículos
Título:
Arsenic absorption and excretion in chronically exposed developing toad Rhinella arenarum
Autor/es:
MARDIROSIAN, MARIANA; BIECZYNSKI, FLAVIA; LUQUET, CARLOS; PÉREZ, CARLOS A.; BONGIOVANNI, GUILLERMINA; LASCANO, CECILIA; VENTURINO, ANDRÉS
Revista:
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Año: 2017 vol. 52 p. 255 - 261
ISSN:
1382-6689
Resumen:
We assessed the toxicodynamics of As in developing Rhinella arenarum toad embryos and larvae exposed from fertilization to 0.01?10 mg As L−1. We determined As content in toad embryos and larvae by X-ray fluorescence spectrometry. Toad embryos and larvae actively bioaccumulated As, reaching tissue concentrations more than one-thousand higher than control levels after 23d-exposure to 10 mg As L−1. The bioconcentration factors also increased up to fifty times higher levels in toad larvae respect to media levels. Once recovered in As-free media, the larvae rapidly excreted the bioaccumulated As with a half-life of 1.6 d. By calcein transport competition assays, we infer that As is excreted through ABCC-like transporters, probably conjugated with GSH. These results are relevant for comprehending the risks posed by As exposure in this autochthonous aquatic species that develops in water courses from Argentina, that may contain As levels ranging between 10?15,000 μg L−1.