INVESTIGADORES
POSTIGO Jose Alberto
artículos
Título:
Transition metal- and organophotocatalyst-free perfluoroalkylation reaction of amino(hetero)aromatics initiated by the complex (TMEDA) I.I3 and visible light
Autor/es:
DAMIÁN YERIEN; ROMINA CONDE; BRUNO CAMPS; BARATA VALLEJO, S; BEATRIZ LANTAÑO; AL POSTIGO
Revista:
Royal Society of Chemistry Advances
Editorial:
ROYAL SOCIETY OF CHEMISTRY
Referencias:
Lugar: Oxford-doi: 10.1039/c6ra24786e; Año: 2017 vol. 2017 p. 266 - 274
ISSN:
2046-2069
Resumen:
doi: 10.1039/c6ra24786eRadical initiation for the perfluoroalkylation reaction of amino(hetero)aromatics has been accomplished employing the complex (TMEDA) I.I3 and visible light. This methodology circumvents the use of metal(organo)catalysts and relies on the well-known iodine atom reaction with perfluoroalkyl iodides to generate perfluoroalkyl radicals RF. Biologically-relevant substrates are easily substituted with RF moieties employing a mild and environmentally benign radical strategy starting from readily-available perfluoroalkyl iodides RFI