Mycobacterium bovis deleted in mce2 and phoP loci protects C57BL/6 mice against tuberculosis

GARCIA E; BIANCO M; BLANCO F; BIGI F

The Journal of Infection in Developing Countries

JIDC

Año: 2016 vol. 10

Mycobacterium bovis, the causative agent of bovine tuberculosis, infects cattle and other animals, including humans. In this study we found that a M. bovis knockout strain in phoP and mce2 operons protected C57BL/6 mice against virulent M. bovis challenge. The double mutant was significantly more attenuated than the parental M. bovis Δmce2 strain in immunodeficient mice.