The genomics of mycobacteria

MARIANA VIALE; MARTIN ZUMARRAGA; FLABIO ARAUJO; ANA MARÍA ZARRÁGA; ANGEL A CATALDI; ROMANO MARÍA ISABEL; FABIANA BIGI

REVUE SCIENTIFIQUE ET TECHNIQUE DE L4OFFICE INTERNATIONAL DES EPIZOOTIES

OFFICE INT EPIZOOTIES

Año: 2016 vol. 35 p. 215 - 240

0253-1933

The species Mycobacterium bovis and Mycobacterium avium subspecies paratuberculosis are the causal agents, respectively, of tuberculosis and paratuberculosis in animals. Both mycobacteria, especially M. bovis, are also important to public health because they can infect humans. In recent years, this and the impact of tuberculosis and paratuberculosis on animal production have led to significant advances in knowledge about both pathogens and their host interactions. This article describes the contribution of genomics and functional genomics to studies of the evolution, virulence, epidemiology and diagnosis of both these pathogenic mycobacteria.