INVESTIGADORES
VILLAR Marcelo Jose
artículos
Título:
Evidence for upregulation of galanin synthesis in rat glial cells in vivo after colchicine treatment
Autor/es:
XU, Z., R. CORTES, M.J. VILLAR, P. MORINO, M-N. CASTEL AND T. HÖKFELT
Revista:
NEUROSCIENCE LETTERS
Editorial:
ELSEVIER IRELAND LTD
Referencias:
Lugar: Amsterdam; Año: 1992 vol. 145 p. 185 - 188
ISSN:
0304-3940
Resumen:
Abstract
The localization of galanin (GAL) and GAL mRNA was studied in rat brain after colchicine or vinblastine treatment using in situ hybridization and immunohistochemistry. GAL-like immunoreactivity was found in glial cells, presumably activated microglia, in the cortex, caudate nucleus and septum, mainly on the injection side. GAL mRNA expression was found in small cells in the same areas with an overlapping distribution, including the adjacent white matter. The results suggest that the glial cells initiate synthesis of the peptide GAL in response to intraventricular injection of high doses of the 2 mitosis inhibitors.
PMID: 1281534 [PubMed - indexed for MEDLINE]
