INVESTIGADORES
IRIBARREN Adolfo Marcelo
artículos
Título:
A Chemoenzymatic Route To Prepare Acyclic Nucleoside Analogues
Autor/es:
M. PALAZZOLO; M. NIGRO; A. IRIBARREN; E. LEWKOWICZ
Revista:
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Editorial:
WILEY-V C H VERLAG GMBH
Referencias:
Lugar: Weinheim; Año: 2016 vol. 2016 p. 921 - 924
ISSN:
1434-193X
Resumen:
Acyclic nucleosides are potential antiviral and antitumor agents. In this work, their preparation through a novel chemoenzymatic procedure involving theN-alkylation of a nucleobase and subsequent aldol condensation catalyzed by a dihydroxyacetone phosphate-dependant aldolase (Rabbit Muscle Aldolase, RAMA) is described.
